Research Scientist I

February 7, 2019 Adam Sychla

Research Scientist I

Company:

Backed by the Silicon Valley accelerator Y Combinator (still “stealth”!), LEAH Labs is looking for a cornerstone Scientist with founder mentality and entrepreneurial spirit to help us “make something people want”. The Scientist will work with the founding team to implement and iterate upon LEAH Labs’ T cell engineering platform. This Scientist will have regular access to our world-class Scientific Founders with deep expertise in T cell therapies, genome engineering and veterinary science. In the spirit of a lean startup culture, the candidate need not have all listed skills so long as they have a willingness to learn and grow with the company. Aspects of this position include: project leadership of this key research team, design and execution of lab experiments, innovative problem solving, and data analysis. A successful candidate will leverage their experience, curiosity, and creativity to design and implement a high-throughput pipeline for T cell engineering.

Responsibilities:
• Develop and enhance T cell engineering pipelines using LEAH’s cutting-edge in-house gene editing platforms
• Create, update, and maintain experimental SOPs as the key basis for downstream protocol development in the vet clinics
• Recommend next steps based on experimental analysis
• Maintain detailed experimental records
• Aid in the hiring and managing of scientific staff for this lead team

Skills and Experience:
• Ph.D. in biochemistry, molecular biology, genetics, or a related discipline
• Direct experience with: T cell culture, in vitro T cell function assays
• Proven record in immuno-oncology or related field
• Expertise in immunology and cell-mediated immunity
• Demonstrated record of innovation in molecular biology and/or cellular assays
• Direct experience with flow cytometry and immunolabeling
• Strong communication and presentation skills
• Willingness to work in a fast-paced, lean startup environment

Desired Traits:
• Familiarity with R programming
• Familiarity with: NGS/sequencing library preparation and analysis, and other genomic platforms
• Experience with lab robotics platforms
• Experience with molecular cloning
• Knowledgeable in DNA repair pathways
• Experience with designer nuclease platforms
• Experience managing people

Benefits:
• Company equity, responsible PTO, paid Holidays, and health care benefits
• Competitive salary commensurate with experience and credentials

“If you love what you do, you’ll never work a day in your life” – cliché, right? Maybe, but our founders live this motto. If you’re looking for a “job”, LEAH Labs probably isn’t for you.

How to Apply
If the above sounds like a great fit, and you’re willing to jump into a fast-paced start-up environment with a growing team of exceptional scientists, please email your C.V. to our CEO, Wes Wierson at wes@leahlabs.com . Included in your email, tell us about a time you “hacked” a non-computer system to your advantage.

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Research Associate- Histology and Molecular Biology

January 25, 2019 Min Lee

Research Associate- Histology and Molecular Biology

Company:

Recombinetics is seeking a highly motivated and creative Research Scientist to take a leading role in cutting edge research and development project in the field of organ regeneration and interspecies chimerism. Recombinetics mission is to create identical replicas of a patient’s own organ cells and tissues — with his or her own DNA — this technology has the potential to transform the face of modern medicine and drastically improve the quality-of-life for millions.

Potential Benefits

A dynamic and highly collaborative working environment
Comprehensive benefits package available, including health, dental, vision, and 401K
Job title and compensation will be based on candidate experience
Recombinetics is an equal opportunity provider and employer

Responsibilities:

The candidate will be responsible to perform all aspects of processing and analyzing cells and tissues for regenerative medicine programs. The laboratory work requires an understanding of mammalian pathology and molecular biology techniques, attention to detail, and quality focused mindset.

The ideal candidate will have demonstrated expertise in histology and molecular biology. The Scientist will have full responsibility to ensure that analyses are established and followed for all histology processes- ensuring the highest standards in laboratory methods to provide quality results.
You will be a team member as part of a fast-paced, collaborative science team, with the expectation to maintain close communication with other scientists.

Essential Duties and Job Functions:

The candidate must think critically and creatively and work independently. We highly value candidates with a collaborative and collegial work ethic, with the ability to deliver results in a dynamic and fast-paced team environment. The candidate should exhibit excellent organizational skills and be proficient in both data management and the preparation of summary reports. The candidate should be able to present clear and concise data summaries in group and team meetings. The candidate should be willing to work weekends in rotation with other colleagues.

Knowledge, Experience and Skills:

MS or equivalent experience in Histology and Molecular Biology or related science
A minimum of 3 years of histology experience, preferably human and mammalian tissue processing.
Expertise in paraffin and frozen sections of mammalian tissues
Experience in various molecular biology methods, including: PCR, qPCR, Southern, Western, Northern, IHC, ICC, FISH, DNA cloning
Experience with various microscopy techniques
Willingness to work with lentiviral vector and human biological samples
Demonstrated ability to create written experimental plans
Ability to keep current with relevant scientific literature
Attention to detail and strong laboratory record keeping is required
Demonstrated proficiency in computer skills
Knowledge of automated laboratory systems is a plus
Excellent problem-solving skills
Strong teamwork and collaboration skills
Must be able to communicate effectively in oral and written formats

Be known by their fellow colleagues as friendly and reliable
Possesses the drive to succeed and to participate in the growth of an exciting, fast-paced company

How to Apply
Send CV credentials and a letter of interest to Tad Sonstegard at tad@recombinetics.com

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Research Scientist – Developmental Immunology

January 25, 2019 Min Lee

Research Scientist – Developmental Immunology

Company:

Potential Benefits

A dynamic and highly collaborative working environment
Comprehensive benefits package available, including health, dental, vision, and 401K
Job title and compensation will be based on candidate experience
Recombinetics is an equal opportunity provider and employer

Responsibilities:

The candidate will be responsible to establish human immunology platforms for various cell culture. Perform all aspects of creating, growing and expanding cells for regenerative medicine programs.

The candidate will possess an extensive understanding of developmental immunology, hematopoietic stem cells differentiation to multiple populations of the hematopoietic lineage.

The ideal candidate will have demonstrated expertise in hematopoietic techniques, attention to detail, and quality focused mindset.

The Scientist will have full responsibility to ensure that procedures are established and followed for all cell culture processes – ensuring the highest standards in laboratory methods to provide quality results.

You will be a team member as part of a fast-paced, collaborative science team, with the expectation is to maintain close communication with other scientists.

Essential Duties and Job Functions:
The candidate must think critically and creatively and work independently. We highly value candidates with a collaborative and collegial work ethic, with the ability to deliver results in a dynamic and fast-paced team environment. The candidate should exhibit excellent organizational skills and be proficient in both data management and the preparation of summary reports. The candidate should be able to present clear and concise data summaries in group and team meetings. A milestone-driven scientist who is able to meet project timelines, completion and budget. The candidate should be willing to work weekends in rotation with other colleagues.

Knowledge, Experience and Skills:

PhD, MD in molecular immunology, developmental immunology or related science
A minimum of 4 years of hematopoietic cell culture experience, preferably human and primary culture
Expertise in culturing and differentiating mammalian pluripotent stem cells to various populations of the hematopoietic lineage
Introduce new methods, platforms and project concepts
Experience in various molecular biology methods, including: PCR, qPCR, Southern, Western, Northern, IHC, ICC, FISH, DNA cloning
Knowledge and proven experience in NGS methods: ChIP, ATAC, RNA-seq, Single-cell RNA-seq, etc.
Extensive experience with flow cytometry, specifically in characterizing multiple populations and subpopulations during embryo development
Experience with various microscopy techniques
Willingness to work with lentiviral vector and human biological samples
Maintain accurate and reliable record keeping including database management, notebooks, and all other pertinent documentation.
Ability to keep current with relevant scientific literature
Demonstrated proficiency in computer skills
Excellent problem-solving skills
Strong teamwork and collaboration skills
Ability to take ownership of projects and results
Must be able to communicate effectively in oral and written formats
Be known by their fellow colleagues as friendly and reliable
Possesses the drive to succeed and to participate in the growth of an exciting, fast-paced company
Knowledge of automated laboratory systems is a plus
Experience in genome engineering technologies such as CRISPR/Cas9 is a plus

How to Apply
Send CV credentials and a letter of interest to Tad Sonstegard at tad@recombinetics.com

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Research Scientist – Molecular and Cell Biology

January 25, 2019 Min Lee

Research Scientist – Molecular and Cell Biology

Company:

Potential Benefits

A dynamic and highly collaborative working environment
Comprehensive benefits package available, including health, dental, vision, and 401K
Job title and compensation will be based on candidate experience
Recombinetics is an equal opportunity provider and employer

Responsibilities:

The candidate will be responsible to perform all aspects of creating, growing and expanding cells for regenerative medicine programs. The laboratory work requires an understanding of pluripotent stem cell biology techniques, attention to detail, and quality focused mindset.

The ideal candidate will have demonstrated expertise in stem cell research and development. The Scientist will have full responsibility to ensure that procedures are established and followed for all cell culture processes- ensuring the highest standards in laboratory methods to provide quality results.
You will be a team member as part of a fast-paced, collaborative science team, with the expectation is to maintain close communication with other scientists.

Knowledge, Experience and Skills:

PhD, MD in Stem Cell Biology, molecular genetics, developmental biology or related science
Experienced with in-vivo animal models.
Knowledge and proven experience in NGS methods: ChIP, ATAC, RNA-seq, Single-cell RNA-seq, etc.
Experience with flow cytometry
Willingness to work with lentiviral vector and human biological samples.
Maintain accurate and reliable record keeping including database management, notebooks, and all other pertinent documentation.
Ability to keep current with relevant scientific literature
Attention to detail and strong laboratory record keeping is required
Demonstrated proficiency in computer skills
Knowledge of automated laboratory systems a plus
Excellent problem-solving skills
Strong teamwork and collaboration skills
Must be able to communicate effectively in oral and written formats
Be known by their fellow colleagues as friendly and reliable
Possesses the drive to succeed and to participate in the growth of an exciting, fast-paced company

How to Apply
Send CV credentials and a letter of interest to Tad Sonstegard at tad@recombinetics.com

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Research Scientist: Molecular Biology & Swine Neuroendocrinology

January 25, 2019 Min Lee

Research Scientist: Molecular Biology & Swine Neuroendocrinology

Focus area: Reproductive Physiology

Company:

Recombinetics is seeking a highly motivated and creative Research Scientist to take a leading role in pioneering research and development in the field of agriculture to improve animal welfare. Through its agriculture subsidiary, Acceligen, Recombinetics aims to eliminate the painful procedure of castration of swine through gene editing. This technology has the potential to transform the pork industry and improve the quality-of-life for millions of pigs.

Potential Benefits

A dynamic and highly collaborative working environment
Comprehensive benefits package available, including health, dental, vision, and 401K
Job title and compensation will be based on candidate experience
Recombinetics is an equal opportunity provider and employer

The Opportunity
• Plan and complete research and development activities to characterize castration free swine in a project funded by the USDA FFAR Animal Welfare grant.
• Collaborative interaction and project support provided by two key international genetics companies. As well as leading swine reproductive physiologists at the USDA-ARS USMARC.
• Project goals are to establish how deletion of kisspeptin 1 by gene editing affects male and female swine physiology in commercial genetic lines.
• Conduct studies in vivo and in primary tissue culture that will involve a range of molecular biology methods.
• Develop immunohistochemical and in situ hybridization techniques to quantify expression.
• Characterize biological variation in the reproductive axis by conducting RNAseq analysis with follow up in proteomic analysis and metabolomic analysis.
• The overall objective is to develop methods for the commercial-scale rescue of puberty and fertility from kisspeptin 1 knock out swine.

Qualifications Required
The applicant must be eligible to work in the United States without restrictions and possess near-native fluency in English, written and oral. The candidate also must have earned a Ph.D. degree within the last six years in Animal Science, Physiology, Molecular Biology or a related field of study. Specialized experience of mammalian neuroanatomy and neuroendocrinology highly desired.

How to Apply
Send CV credentials and a letter of interest to Tad Sonstegard at tad@recombinetics.com

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